Volume No. :   1

Issue No. :  1

Year :  2009

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology



Address:   Suryawanshi CP*1, Patil VR1, Chaudhari RY1, Kale MK3, Firake SD3, Pimprikar RB2, Patil MD2, Yeshwante SB2 and Saindanem DS2
1Tapi Valley Education Society’s Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS)
2Nagaon Education Society’s Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS)
3K.Y.D.S.C.T’s College of Pharmacy, Sakegaon, Tal- Bhusawal, Dist. Jalgao
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The Parkinson’s disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson’s symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson’s symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson’s symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson’s disease.
KEYWORDS:
Parkinson’s disease, oxotremorine, tremor, procyclidine.
Cite:
Suryawanshi CP, Patil VR, Chaudhari RY, Kale MK, Firake SD, Pimprikar RB, Patil MD, Yeshwante SB, Saindanem DS. Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology. Research J. Pharmacology and Pharmacodynamics. 2009; 1(1): 35-38.
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