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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Anti-inflammatory Activity of a Protease Extracted from the Fruit Stem Latex of the Plant Artocarpus heterophyllus Lam.
Smriti Rekha Chanda
Sadhan Kr Dutta.
rat paw oedema
Indranil Chanda1*, Smriti Rekha Chanda1 and Sadhan Kr Dutta2
1Department of Pharmacy, Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati – 781017, Assam, India
2Department of Pharmacy, Gupta College of Technological Sciences, Asansol- 713301 West Bengal, India
The anti-inflammatory activity of the new protease fraction Artocarpain-H extracted from the fruit stem latex of the plant Artocarpus heterophyllus Lam. was evaluated using Carrageenan induced rat paw oedema and Cotton pellet-induced granuloma model. The Artocarpain-H dose dependently inhibited carrageenan induced rat paw edema. It also showed reduction on the granuloma weight in the cotton pellet granuloma method.. In the present investigation, as the test drug is effective in both models of inflammation, there is a possibility that these drugs may be effective in acute and chronic inflammation.
Indranil Chanda, Smriti Rekha Chanda , Sadhan Kr Dutta. Anti-inflammatory Activity of a Protease Extracted from the Fruit Stem Latex of the Plant Artocarpus heterophyllus Lam. Research J. Pharmacology and Pharmacodynamics. 2009; 1(2): 70-72
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