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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Study of Anti-Inflammatory potential of Ethanolic Fraction of Seeds of Ocimum basilicum Linn.
Pankaj Rakha1*, Manju Nagpal1, Sunil Sharma2 and Milind Parle2
1Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa- 125055
2Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana) India.
In the present study the ethanolic fraction of seeds of the plant Ocimum basilicum Linn. was taken and its anti-inflammatory potential was evaluated using carrageenan and formalin induced rat paw edema. The effect on chronic phase of inflammation was also studied using cotton pellet granuloma technique. The increase in paw thickness was measured using digital vernier caliper after 1,2,3 and 4h of injection. Ethanolic fraction of the seeds of the plant at dose of 400 mg/Kg significantly inhibited acute phase of inflammation. The decrease in the weight of granuloma was also found by ethanolic fraction of the seeds at same dose. The study reveals that the ethanolic fraction of seeds of Ocimum basilicum Linn. possesses significant anti-inflammatory activity.
Anti-inflammatory, carrageenan, formalin, granuloma.
Pankaj Rakha, Manju Nagpal, Sunil Sharma, Milind Parle. Study of Anti-Inflammatory potential of Ethanolic Fraction of Seeds of Ocimum basilicum Linn. Research J. Pharmacology and Pharmacodynamics. 2009; 1(2): 79-81.
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