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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Immunostimulant Activity of Aqueous Extract Roots of Glycyrrhiza glabra
Akash P Dahake
Prashant Bagherwal1, Akash P Dahake2* and Chirantan Chakma2
1Bhupal Nobel’s College of Pharmacy, Udaipur, Rajasthan, India.
2Pharmacy College, Rampura, Godhra, Gujarat, India.
Aqueous extract of roots of Glycyrrhiza glabra was evaluated for immunomodulatory activity using E.coli induced abdominal sepsis, Carbon clearance test, Haemagglutination antibody titre value and delayed type hypersensitivity at different dose levels i.e. 75, 150 and 300 mg/kg of body weight p.o. The results of the studies were compared with the control group. The extract was found to be effective in reducing mortality in E.coli induced abdominal sepsis. The immunostimulant effect was observed with increased phagocytosis in carbon clearance test. The extract was found to have significant immunostimulant activity in haemaggultination antibody titre value and delayed type hypersensitivity at dose levels of 150 and 300 mg/kg of body weight.
Glycyrrhiza glabra, Sepsis, Haemagglutination, Hypersensitivity
Prashant Bagherwal, Akash P Dahake, Chirantan Chakma Immunostimulant Activity of Aqueous Extract Roots of Glycyrrhiza glabra. Research J. Pharmacology and Pharmacodynamics. 2009; 1(3):120-124.
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