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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Effect of Chlorophytum borivilianum on Fluoxetine Induced Sexual Dysfunction in Female Rats
Imtiyaz Ansari and Amol Bhandare.
Neeraj Vyawahare, Virendra Kagathara*, Rohini Pujari, Manoj Patil, Imtiyaz Ansari and Amol Bhandare
AISSMS College of Pharmacy, Kennedy Road, Nr. RTO, Pune-411001, Maharashtra, India.
Treatment with selective serotonin reuptake inhibitors (SSRI’s) has been shown to cause reduced libido in women. A large body of evidence suggests that serotonin may influence sexual behavior in estradiol + progesterone primed, ovariectomized female rats. In the present study, the effect of 2 weeks of fluoxetine administration (10 mg/kg daily) and co administration of fluoxetine (same dose) and hydroalcoholic extract of Chlorophytum borivilianum (CB) (100, 300 and 500 mg/kg daily) on copulatory behavior in hormone primed ovariectomized rats was investigated. Fluoxetine significantly reduced various proceptive and receptive behaviors of female rats as compared to normal rats. In contrast, these behavioral parameters were significantly increased by co administration of various doses of CB with fluoxetine as compared to fluoxetine treated rats. The results point towards the potential role and probable use of CB in females with antidepressant induced reduced libido.
Chlorophytum borivilianum; fluoxetine; libido; ovariectomized; proceptive; receptive
Neeraj Vyawahare, Virendra Kagathara, Rohini Pujari, Manoj Patil, Imtiyaz Ansari and Amol Bhandare. Effect of Chlorophytum borivilianum on Fluoxetine Induced Sexual Dysfunction in Female Rats. Research J. Pharmacology and Pharmacodynamics. 2009; 1(3):130-133.
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