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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Local Anaesthetic Activity of Calotropis gigantea Latex in Frog and Guinea Pig
B Gowtham Kumar
KK Rajasekhar*, V Shankarananth, M Rajagowtham, B Gowtham Kumar, B Thejnayan and M Pavankumar
Dept of Pharmaceutical chemistry, Sri Padmavathi School of Pharmacy,Tiruchanoor, Tirupati-517503, A.P.,India.
This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution ) exhibited significant local anaesthetic activity.
Calotropis gigantea,milky latex,local anaesthetic activity,nerve block method,muscle twitch method and infiltration method .
KK Rajasekhar, V Shankarananth, M Rajagowtham, B Gowtham Kumar, B Thejnayan, M Pavankumar. Local Anaesthetic Activity of Calotropis gigantea Latex in Frog and Guinea Pig. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):178-180.
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