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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Potentiation of Local Anesthetic Activity of Calotropis gigantea Latex with Epinephrine and pH In Guinea Pig
V Swetha Reddy.
K. K. Rajasekhar*, V. Shankarananth, C. Sreelakshmi, A. Sushmitha, S. Ch. Moulali and V. Swetha Reddy.
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503,A.P. India.
The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea,with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5µg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.
Calotropis gigantea, Milky latex, Epinephrine, pH and Infiltration anesthesia
KK Rajasekhar, V Shankarananth, C Sreelakshmi, A Sushmitha, SCh Moulali, V Swetha Reddy. Potentiation of Local Anesthetic Activity of Calotropis gigantea Latex with Epinephrine and pH In Guinea Pig. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):198-200.
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