Volume No. :   2

Issue No. :  2

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Potentiation of Local Anesthetic Activity of Calotropis gigantea Latex with Epinephrine and pH In Guinea Pig



Address:   K. K. Rajasekhar*, V. Shankarananth, C. Sreelakshmi, A. Sushmitha, S. Ch. Moulali and V. Swetha Reddy.
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503,A.P. India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea,with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5µg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.
KEYWORDS:
Calotropis gigantea, Milky latex, Epinephrine, pH and Infiltration anesthesia
Cite:
KK Rajasekhar, V Shankarananth, C Sreelakshmi, A Sushmitha, SCh Moulali, V Swetha Reddy. Potentiation of Local Anesthetic Activity of Calotropis gigantea Latex with Epinephrine and pH In Guinea Pig. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):198-200.
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