Volume No. :   2

Issue No. :  4

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Effect of Allium sativum in Immoblilization Stress Induced Albino Rats.



Address:   Roshan S.2, Abdullah Khan2, Sadath Ali1* and Tazneem B.1
1Luqman College of Pharmacy, Gulbarga, Karnataka.
2Department of Pharmacy, Singhania University, Rajasthan.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.
KEYWORDS:
Immobilization stress, Allium sativum, Cortisol, WBC, BUN.
Cite:
Roshan S, Abdullah Khan, Sadath Ali, Tazneem B. Effect of Allium sativum in Immoblilization Stress Induced Albino Rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 293-295.
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