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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Antidiabetic Activity of Swietenia mahagoni Seed Powder in Alloxan Induced Diabetic Mice
R. Sathish1*, K. Natarajan2 and S. Selvakumar3
1Department of Pharmacology, 2Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai.
3Department of Pharmacology, Madurai Medical College, Madurai.
Swietenia mahagoni (Meliaceae) is an evergreen hard wood timber species widely distributed in India and has ethno medicinal uses in malaria, diabetes, anemia, diarrhoea, fever, and dysentery. In this present study antidiabetic effect of Swietenia mahagoni seeds were evaluated in alloxan induced diabetic mice. Blood and urine Glucose levels, food and water consumptions and histopathological studies were determined. In diabetic mice, Swietenia mahagoni seeds significantly reduced the elevated blood glucose level by 43.92% at 500mg/kg and 42.47% at 250mg/kg compared to vehicle treated diabetic mice, without increase in urine glucose, food and water intake. The experimental data indicated that Swietenia mahagoni demonstrated significant antidiabetic action in alloxan induced diabetic mice and could be a potential orally active drug for diabetes mellitus.
Antidiabetic, Indian Mahogany, Alloxan, diabetic mice, Swietenia.
R Sathish, K Natarajan, S Selvakumar. Antidiabetic Activity of Swietenia mahagoni Seed Powder in Alloxan Induced Diabetic Mice. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 296-299.
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