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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Volume No. :
2
Issue No. :
4
Year :
2010
ISSN Print :
0975-4407
ISSN Online :
2321-5836
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Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats
U.S. Mahadeva Rao
,
Bizuneh Adinew
raousm@gmail.com
Address:
U.S. Mahadeva Rao and Bizuneh Adinew
Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, Ethiopia, East Africa
*Corresponding Author
DOI No:
Not Available
ABSTRACT:
In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.
KEYWORDS:
Avocado. Anti-ulcerogenic effect. Indomethacin- induced gastric lesion. Ethanol- induced gastric lesion. Ulcer index
Cite:
U.S. Mahadeva Rao and Bizuneh Adinew. Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 303-308.
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