Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats

U.S. Mahadeva Rao; Bizuneh Adinew

Volume No. :   2

Issue No. :  4

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836

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Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats

U.S. Mahadeva Rao, Bizuneh Adinew

raousm@gmail.com

Address:

U.S. Mahadeva Rao and Bizuneh Adinew
Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, Ethiopia, East Africa
*Corresponding Author

DOI No: Not Available

ABSTRACT:

In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.

KEYWORDS:

Avocado. Anti-ulcerogenic effect. Indomethacin- induced gastric lesion. Ethanol- induced gastric lesion. Ulcer index

Cite:

U.S. Mahadeva Rao and Bizuneh Adinew. Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 303-308.

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