Volume No. :   2

Issue No. :  5

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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To Study the Effect of Allium sativum on various Biochemical Parameters on Stress Induced in Albino Rats



Address:   Roshan S, Tazneem B, Abdullah Khan and Sadath Ali*
Luqman College of Pharmacy, Gulbarga, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH¬of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH ¬of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.
KEYWORDS:
Cold stress, Allium sativum, WBC, BUN
Cite:
Roshan S, Tazneem B, Abdullah Khan,Ali. To Study the Effect of Allium sativum on various Biochemical Parameters on Stress Induced in Albino Rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(5): 335-339.
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