Volume No. :   2

Issue No. :  5

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine–An Induced Hepatotoxicity



Address:   Ajay Kshirsagar1*, Deepa Ingawale2, Purnima Ashok3, Vrushali Thorve2, Tanmay Dodal2, Anurag Dodal2, Mahesh Kahane2 and Bharat Zope2
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India.
2AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India.
3Department of Pharmacology, K.L.E.S’s College of Pharmacy, Bangalore-560010
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250 mg/kg and 500 mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250 mg/kg and 500 mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Further histopathological studies support the above finding.
KEYWORDS:
Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity.
Cite:
Ajay Kshirsagar, Deepa Ingawale, Purnima Ashok, Vrushali Thorve, Tanmay Dodal, Anurag Dodal, Mahesh Kahane, Bharat Zope. Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine–An Induced Hepatotoxicity. Research J. Pharmacology and Pharmacodynamics. 2010; 2(5): 343-347.
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