Volume No. :   2

Issue No. :  6

Year :  2010

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage



Address:   Jyothi Y.1*, Kiran Kumar2, Reddy Shashidhar3 and Dey Tathagata1
1East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049
2Aurobindo Pharma Ltd, Jadcherla, Mahabub Nagar, Andra Pradesh.
3Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore- 560 099
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The hexane extract of Coleus forskohlii (CFHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The CFHE was given in two different doses (27.5mg/kg p.o. and 55mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of CFHE (27.5mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of CFHE was supported by changes in histopathology. It was concluded that hexane extract of CFHE in lower doses possess hepatoprotective activity.
KEYWORDS:
Coleus forskohlii, hepatoprotective, carbon tetrachloride, paracetamol, thioacetamide
Cite:
Jyothi Y, Kiran Kumar, Reddy Shashidhar, Dey Tathagata. Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage. Research J. Pharmacology and Pharmacodynamics. 2010; 2(6): 380-383.
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