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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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The Quantitative detection of different types of Hb variants through HPLC Technique: Report of 428 cases in Indian population.
S K Mohapatra
S N Das
Abhinav Shrivastava*, S.K. Mohapatra, Arpita Roy, S. N. Das and Gaurav Tyagi
Gayatri College of Pharmacy, Sambalpur, Odisha.
Identification of disorder like thalassemia syndromes is immensely important epidemiologically and aid in prevention of more serious hemoglobin disorders. High performance liquid Chromatography (HPLC) forms an important tools and accurate and speedy diagnosis of various hemoglobin disorders. The study was performed on BIO RAD Variant using beta thalassemia short program. The blood samples are taken from various age groups. Abnormal hemoglobin fraction on HPLC was seen in 69 cases of the 428 cases displayed. Detection of this abnormal hemoglobin particularly keeping in mind in high prevalence of Hb A2 will help in prevention of more serious hemoglobinopathies including beta thalassemia major. HPLC form a rapid and accurate tool in early detection and management of various hemoglobin disorders
HPLC, hemoglobin variant, thalassemia
Abhinav Shrivastava, S K Mohapatra, Arpita Roy, S N Das, Gaurav Tyagi. The Quantitative detection of different types of Hb variants through HPLC Technique: Report of 428 cases in Indian population. Research J. Pharmacology and Pharmacodynamics. 2010; 2(6): 397-400.
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