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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract.
Lakshman Kumar D
Sathis Kumar D
Lakshman Kumar D.1, Rao K.N.V.2*, Bindu Madhavi2, Sathis Kumar D.2, and David Banji2
1Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh
2Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh.
Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.
Wrightia tinctoria Roxb, Schrebera swietenoides Roxb, Maltase, Acarbose
Lakshman Kumar D, Rao KNV, Bindu Madhavi, Sathis Kumar D, David Banji. Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract. Research J. Pharmacology and Pharmacodynamics. 2011; 3(1): 22-24
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