Volume No. :   3

Issue No. :  2

Year :  2011

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Anticonvulsant Activity of Leaf Extracts of Anacardium occidentale. Linn.



Address:   Syed Safiullah Ghori1*, Md. Shamim Qureshi1, Mohammed Safwan Ali Khan2, Asma Khanam1, and Jitendra Patel3
1Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, Andhra Pradesh, India.
2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia – Serdang 43400, Selangor Darul Ehsan, Malaysia.
3Bharat Institute of Technology, Ibrahimpatnam, RR. Dist., Hyderabad - 500001. Andhra Pradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aim of the present study was to investigate the anticonvulsant effect of methanolic and aqueous extracts of the leaves of Anacardium occidentale Linn. on electrically and chemically induced seizures. The methanolic and aqueous extracts of the leaves of A. occidentale ( 250 and 500 mg/kg.b.w. p.o.) were studied for the anticonvulsant effect on Maximum electroshock (MES) and Pentylene tetrazole (PTZ) induced convulsions in mice. The latency of onset of tonic-clonic convulsions and the number of animals protected from tonic convulsions were noted. AOMEE and AOAQE (500 mg/kg.b.w.p.o) significantly reduced the onset and duration of seizures induced by maximal electroshock (MES). The same dose also protected animals from pentylene tetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures.
KEYWORDS:
Anacardium occidentale, Anticonvulsant Activity, MES and PTZ induced convulsions.
Cite:
Syed Safiullah Ghori, Md. Shamim Qureshi, Mohammed Safwan Ali Khan, Asma Khanam, Jitendra Patel. Anticonvulsant Activity of Leaf Extracts of Anacardium occidentale. Linn. Research J. Pharmacology and Pharmacodynamics. 2011; 3(2): 72-76.
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