Volume No. :   3

Issue No. :  3

Year :  2011

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Evaluation of Antidepressant Activity of Ailanthus excelsa roxb. using Mice as Experimental animal.



Address:   Khushbu Chauhan*1, Payal Santwani1, Lalkrushn Parmar2, Roshni Solanki1 and Subodh Adeshara1
1Faculty of Pharmacy, Dharmsinh Desai University, College Road, Nadiad- 387001.
2Shree Swaminarayan College of Pharmacy, Village- Saij, NH-8, Kalol-382721.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Introduction: Ailanthus excelsa Roxb. is a tree belonging to family Simaroubaceae, commonly known as a plant of Heaven. The bark of the plant is reported for various pharmacological activities including ear ache, aantimicrobial, anti-viral, antitumor, cytotoxic, hypotensive, abortifacient, diabetes mellitus, obesity and various uterine disorders in Ayurveda. Methanolic extract of Ailanthus excelsa (MeAe) in 150 mg/kg and 100 mg/kg doses are used for evaluation of antidepressant activity. Objective: To evaluate antidepressant activity of Ailanthus excelsa Roxb. using mice as experimental animal by actophotometer and forced swim induced despair behaviour methods. Methods: Swiss albino mice were randomly allocated to 4 groups (n=6); Group I (Normal Control), Group II (Standard group), group III and Group IV (Test Groups). Group I received distilled water while Group II, III and Group IV received Fluoxetine (10 mg/kg, i.p), MeAe 100 mg/kg and 150 mg/kg per oral respectively. Stem bark was extracted by cold maceration process. Antidepressant activity was estimated by actophotometer and forced swim induced despair behaviour methods. Results: MeAe at dose of 150 mg/kg showed highly significant (p<0.01) increase in locomotion and decrease in immobility period while MeAe 100 mg/kg showed significant results in both methods. Conclusion: MeAe (150 mg/kg and 100 mg/kg) has antidepressant activity in mice.
KEYWORDS:
Ailanthus excelsa Roxb., antidepressant activity, actophotometer, forced swim behaviour and MeAe.
Cite:
Khushbu Chauhan, Payal Santwani, Lalkrushn Parmar, Roshni Solanki. Subodh Adeshara. Evaluation of Antidepressant Activity of Ailanthus excelsa roxb. using Mice as Experimental animal. Research J. Pharmacology and Pharmacodynamics. 2011; 3(3): 102-104.
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