Volume No. :   3

Issue No. :  3

Year :  2011

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Effect of Superoxide Dismutase Mimetic Tempol on Dexamethasone Induced Insulin Resistance-Role of Oxidative Stress.



Address:   Karnakumar V. Biradar1*, Chandrashekhar B. Patil1, Basavaraj V. Chivde2, M. H. Malipatil3 and Sanjivkumar D. Biradar1
1R.R.K.S College of Pharmacy, Bidar, Karnataka (India).
2S.V.E.T College of Pharmacy, Humnabad, Bidar Karnataka (India).
3Karnataka College of Pharmacy, Bidar Karnataka (India).
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Glucocorticoids like Dexamethasone are widely used Immunosuppressant and Anti-inflammatory agent. They have several adverse effects, majorly Insulin Resistance (IR) and Hypertension these are probably attributed to Oxidative Stress. In the present study, effect of SOD Mimetic Tempol (2,2,6,6,-tetramethyl-4-hydroxy-1-piperidinyloxy) was administered (1mmol/L) for Prophylactic as well as Therapeutic regimen in Experimental Induced Insulin Resistance in male Wister rats by using Dexamethasone (20µg/kg) subcutaneously and estimated Plasma Insulin and TBARS were measured in Plasma as well in isolated Aortic tissue as a marker of Oxidative Stress. HOMA-IR index and Mastuda Index were calculated as an Insulin Resistance/ Insulin Sensitivity. From the finding of present study, Tempol failed to produce any effect on IR so in conclusion, Oxidative Stress may be playing the Initiative role in Dexamethasone Induced IR.
KEYWORDS:
Insulin Resistance (IR), Oxidative Stress, Dexamethasone, Insulin Resistance Index (HOMA- IR) and Insulin Sensitivity Index (MASTUDA INDEX).
Cite:
Karnakumar V Biradar, Chandrashekhar B Patil, Basavaraj V Chivde, MH Malipatil, Sanjivkumar D Biradar. Effect of Superoxide Dismutase Mimetic Tempol on Dexamethasone Induced Insulin Resistance-Role of Oxidative Stress. Research J. Pharmacology and Pharmacodynamics. 2011; 3(3): 134-137.
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