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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Antidiabetic and Antihyperlipidemic Activity of Roots of Matricaria recutita on Streptozotocin-Induced Diabetic Rats
Krishna Murti1*, Mayank Panchal1, Megha Shah1 and Vijay Lambole1
Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India
The present study was aimed to evaluate the anti diabetic - activity of Matricaria recutita roots against Streptozotocin (STZ) induced experimental rats. Ethanolic extract of roots of Matricaria recutita was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Matricaria recutita (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Matricaria recutita (400 mg/kg). An ethanolic extract of Matricaria recutita was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Matricaria recutita on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Matricaria recutita possesses a hypoglycemic and antihyperlipidemic effect.
Matricaria recutita, Glibenclamide, Hypoglycemia, Antihyperlipidemic, Streptozotocin
Krishna Murti, Mayank Panchal, Megha Shah, Vijay Lambole. Antidiabetic and Antihyperlipidemic Activity of Roots of Matricaria recutita on Streptozotocin-Induced Diabetic Rats. Research J. Pharmacology and Pharmacodynamics. 2011; 3(4): 180-183.
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