Volume No. :   3

Issue No. :  4

Year :  2011

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Ameliorative Role of Threshold Level of Bilirubin in Newborn Jaundice and Efficacy of Noni Fruit Extract on Phenyl Hydrazine Induced Jaundice Rat



Address:   U.S. Mahadeva Rao1*, B. Arirudran 1 and S. Subramanian2
1Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203
2Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aims of the present work were to elucidate the role of bilirubin as a free radical scavenger in unconjugated hyperbilirubinemic newborns. Bilirubin above an optimum level is toxic to human systems and is extcreted in urinary and through gastrointestinal tract. It is observed that serum bilirubin up to 85µmole/l (5mg/dl) has a free radical scavenger activity and exceeding 200µmole/l (12mg/dl) is highly pro-oxidant. Phototherapy is the accepted therapeutic management of jaundiced newborns and has been shown to augment the oxidative stress. The ethanolic extract of Noni fruit administered orally at a dose of 3mg/ml is found to diminish the oxidative stress in erythrocytes of phenylhydrazine –induced unconjugated hyperbilirubinemic jaundiced rats, treated with phototherapy, which ultimately reduces the bilirubin level without inducing additional damages.
KEYWORDS:
Bilirubin, free radical scavenger, Pro-oxidant, Phototherapy, jaundice, Oxidative stress, Noni
Cite:
US Mahadeva Rao, B Arirudran , S Subramanian. Ameliorative Role of Threshold Level of Bilirubin in Newborn Jaundice and Efficacy of Noni Fruit Extract on Phenyl Hydrazine Induced Jaundice Rat. Research J. Pharmacology and Pharmacodynamics. 2011; 3(4): 196-201.
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