Volume No. :   3

Issue No. :  4

Year :  2011

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats



Address:   Prasad K.1, Nitin M.2*, Chetan M.2, Girish M.2 and Krishna Kumar2
1Shri Vishnu College of Pharmacy, Bhimavaram-534202, A.P.
2HKES College of Pharmacy, Department of Pharmacology, Gulbarga-585105, Karnataka, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Peptic ulcer is a chronic and appalling disease. Today, it is dominant among the diseases that affect the world’s population. The principal factors causing this disease are inadequate dietetic habits, prolonged use of non-steroidal anti-inflammatory drugs, stress and infection by Helicobacter pylori, in addition to other factors of genetic origin. The present study was designed to evaluate the combination effect of vitamin E with lansoprazole against pylorus ligation induced ulcer model in rats. The antiulcer effect of the combination of vitamin E 0.9mg/200g and lansoprazole 0.54mg/200g b.w orally was compared with the reference standard lansoprazole 0.54mg/200 g b.w orally. The ulcer index and other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice were estimated. The ulcer index and other biochemical parameters like volume (***P < 0.001), free acidity (***P < 0.001), total acidity (***P < 0.001) and pH (**P < 0.01), of gastric juice showed reduction when compared to standard lansoprazole. The percentage protection of combination was 92.9% as compared to standard lansoprazole 82.8%. Thus the combination group was found to be synergistic in nature when compared to lansoprazole alone.
KEYWORDS:
Antiulcer activity, vitamin E, lansoprazole, pylorus ligation model, ulcer index.
Cite:
Prasad K, Nitin M, Chetan M, Girish M, Krishna Kumar. Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats. Research J. Pharmacology and Pharmacodynamics. 2011; 3(4): 202-206.
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