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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Elevated Singlet Oxygen Dependent Tissue Injury As Well As Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children.
US Mahadeva Rao.
N.Sangeetha1 and U.S. Mahadeva Rao2*
1PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203. India.
2Associate Professor, Faculty of Medicine and Health Science, Universititi Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, Malaysia.
The study was aimed to determine the biochemical changes in the free radical profile and antioxidant enzyme status in epileptic children before and after treatment with VPA monotherapy. Methods: We have studied the levels of serum LPO (MDA), erythrocyte antioxidants (GSH, GPx, SOD and CAT) in 25 epileptic children before and after treatment with sodium valproate and compared them against 25 healthy children. Results: The results showed that MDA levels were increased (p<0.001) in epileptic children under VPA treatment compared to the controls. Antioxidant enzymes GPx, SOD, CAT activities were decreased (p<0.001) in epileptic children receiving VPA monotherapy whereas no significant changes when compared between before and after treatment with VPA. The level of GSH was also decreased (p<0.001) in follow-up cases of epileptic children receiving VPA therapy. Conclusion: It was hypothesized that the oxidants-antioxidants balance were modified further by sodium valproate in epileptic children.
Sodium valproate, antioxidants, lipid peroxidation, oxidative stress, epilepsy, free radical
N Sangeetha, US Mahadeva Rao. Elevated Singlet Oxygen Dependent Tissue Injury As Well As Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children. Research J. Pharmacology and Pharmacodynamics. 2011; 3(6): 307-310
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