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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Potential of Carica papaya against Gentamicin Induced Nephrotoxic Rats
Saranya S. and Anuradha R.*
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PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women’s College, Mannargudi – 614001, Tamil Nadu, India.
The present study was desined to evaluate the nephroprotective effect of ethanolic extracts of seeds of Carica papaya against gentamicin induced nephrotoxicity in albino rats. Oral administration of gentamicin (5mg/100g body weight/day) shows the significantly reduction in serum urea, uric acid, creatinine and protein, level were significantly decreased when compared to the control rats. Ethanolic extracts of seeds of Carica papaya administration (40 mg/kg b. wt/day) brought about the significant changes in biochemical parameters. The present work indicates that the Carica papaya extracts has showed their protective role against gentamicin induced nephrotoxicity and its more effective in preventing kidney damage that treating it.
Nephrotoxicity, renal markers, gentamicin, Carica papaya
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