Volume No. :   4

Issue No. :  2

Year :  2012

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Diuretic activity of whole plant extract of Leptadenia reticulata



Address:   S. Mohanraj1*, Santhoshkumar C. 2 and A. Chandran3
1Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, Andhra Pradesh, India
2Srikrupa Institute of Pharmaceutical Sciences, Siddipet. Andhra Pradesh, India
3PGP College of Pharmaceutical Science & Research Institute, Namakkal,
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was undertaken to investigate the diuretic effect of aqueous and ethanolic extract of the Whole plant of Leptadenia reticulata in normal rats. Aqueous and ethanolic extracts of whole plants of Leptadenia reticulata were administered to experimental rats orally at doses of 100mg/kg p.o. Furosemide (100 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Urine volume was significantly increased by both aqueous and ethanolic extract in comparison to the control group but this effect was less than furosemide. Significant increase in renal clearance of sodium, potassium and chloride ions was observed in treated and standard groups.
KEYWORDS:
Diuretic activity, Furosemide, Leptadenia reticulata, aqueous and ethanol
Cite:
S Mohanraj, Santhoshkumar C , A Chandran. Diuretic activity of whole plant extract of Leptadenia reticulata. Research J. Pharmacology and Pharmacodynamics. 2012; 4(2): 84-86.
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