Volume No. :   4

Issue No. :  2

Year :  2012

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Chemopreventive potential of Aegle marmelos fruit extract against 7,12-Dimethylbenz (a)anthracene-Induced Skin Papillomagenesis in Mice



Address:   Nirmala Gupta1*, R.C. Agrawal1, Vinoy Shrivastava2, Amit Roy3 and Pushpa Prasad3
1Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
2Deptt. of Biosciences, Barkatullah University, Bhopal (MP), India
3 Columbia Institute of Pharmacy, Raipur
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104µg/100µl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice
KEYWORDS:
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin carcinogenesis, Glutathione..
Cite:
Nirmala Gupta, RC Agrawal, Vinoy Shrivastava, Amit Roy , Pushpa Prasad. Chemopreventive potential of Aegle marmelos fruit extract against 7, 12-Dimethylbenz (a)anthracene-Induced Skin Papillomagenesis in Mice. Research J. Pharmacology and Pharmacodynamics. 2012; 4(2): 87-90 .
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