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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Anti-arthritic and anti-inflammatory effect of Cetylmyristeolate against Freund’s adjuvant induced arthritis model
Kayalvizhi M.K.1*, Vanitha Samuel1, P. Nirmala1 and K. Balamurugan2
1Division of Pharmacology, RMMC and H, Annamalai University, Annamalai Nagar, Chidambaram.
2Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram.
To evaluate the effect of Cetylmyristeolate (CMO) in Freund’s complete adjuvant induced arthritis in rats. The experimental study was evaluated on male and female Wister rats weighing (150 – 200gms). 0.5 ml of Freund’s complete adjuvant (FCA) in the left tibiotarsal joint (IA) was injected to induce arthritis, CMO-500mg; 1g and CMO100mg + MSM200mg + glucosamine 500mg /day for 21 days were given. Paw edema by plesthysmometer and arthritic index were studied, the results showed marked reduction of arthritic and inflammatory effect by CMO500mg/day and 1gm/day as well as the combination of 100mg/day + glucosamine 500mg and MSM 200mg /day. Percentage inhibition of paw volume edema was statistically significant and reductions in the arthritic index scores were comparable with reference standard drug dexamethasone. From the results of this study, it was concluded that CMO as well as the combinations produced a statistically significant effect in reducing carrageenan induced arthritis in rats.
Cetyl myristoleate (CMO), Glucosamine sulphate, Methyl sulfonyl methane (MSM), Dexamethasone, Arthritis.
Kayalvizhi MK, Vanitha Samuel, P Nirmala , K Balamurugan. Anti-arthritic and anti-inflammatory effect of Cetylmyristeolate against Freund’s adjuvant induced arthritis model. Research J. Pharmacology and Pharmacodynamics. 2012; 4(2): 91-93.
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