Volume No. :   4

Issue No. :  4

Year :  2012

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole plant in Mice



Address:   Diana Vivian Atigari1*, Mrs. Sunanda Sabbithi1, Krishna Chaitanya B.1, Jajisree A.2, Dr. Ramesh. C.2
1Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet), Secunderabad 500014, AP, India.
2GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the present study was to investigate the CNS depressant and Anxiolytic activity of the methanolic extract of the whole plant of Celastrus paniculatus Willd. (Family: Celastraceae) in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract (200 mg/kg, 400mg/kg and 600 mg/kg) on the central nervous system (CNS) was evaluated for potentiation of phenobarbitone-induced sleeping time in mice. The results revealed that the methanolic extract of Celastrus paniculatus Willd. whole plant has reduced the onset of Phenobarbitone-induced sleeping time in mice and prolonged the duration of sleeping time significantly (p<0.05). In the test studied for the anxiolytic activity of methanolic extract of Celastrus paniculatus Willd. whole plant, using Staircase test model, it was revealed that the extract at doses 200 mg/kg and 400mg/kg reduced the number of rearings and decreased the number of steps ascended significantly (p<0.05). The overall results suggest that the methanolic extract of Celastrus paniculatus Willd. whole plant contains some active principles which may possess significant CNS depressant and anxiolytic activity.
KEYWORDS:
Celastrus paniculatus Willd., CNS depressant, Anxiolytic, potentiation of phenobarbitone-induced sleeping time, Staircase test.
Cite:
Diana Vivian Atigari, Mrs. Sunanda Sabbithi, Krishna Chaitanya B, Jajisree A, Ramesh C. Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole plant in Mice. Research J. Pharmacology and Pharmacodynamics. 2012; 4(4): 245-250 .
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