Volume No. :   4

Issue No. :  5

Year :  2012

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Hepatoprotective Effect of Ethanolic and Hydro Alcoholic Leaf Extract of Madhuca indica in Carbon Tetra Chloride Intoxicated Rat



Address:   Pushpendra K. Patel1*, Jyoti Sahu1, Narendra K. Prajapati1, B.K. Dubey1, A. Alia2
1T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal. M.P.
2Rajiv Gandhi College, Bhopal
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion. This organ plays a major role in metabolism and has a number of functions in the body including glycogen synthesis, hormone production, and detoxification. Excess consumption of N.S.A.I.D. and alcohol causes the liver disease. Madhuca indica that is also known as mahua in different parts of the country belonging to the family Sapotaceae is having several medicinal properties. The leaves of Mahua tree contain saponin, an alkaloid, and glucoside. Sapogenin and other basic acid are found in the seeds. Various Photochemical studies on Mahua include characterization of Sapogenin, triterpenoids, steroids, saponin, flavonoids and glycosides. Madhuca indica has several pharmacological activity, and potential to provide health to the society. It is used as Anti diabetic, antiulcer, hepato protective, anti pyretic, anti fertility, analgesic, anti oxidant, swelling, inflammation, piles, emetic, dermatological, laxative, tonic, anti burn, anti earth worm, wound healing headache and many more problems. The ethanolic extract of Madhuca indica at 200 mg/kg and 400 mg/kg produce significant hepatoprotective effect against paracetamol induced hepatotoxicity. Different parameters such as physical, Histopathological and biochemical studies like ALT, SGOT, SGPT, bilirubin test had been included in the study which provides the satisfactory data to conclude the hepatoprotective effects of Madhuca indica.
KEYWORDS:
Madhuca indica, mahua, hepatoprotective, CCl4, liver disease
Cite:
Pushpendra K Patel, Jyoti Sahu, Narendra K Prajapati, BK Dubey, A Alia. Hepatoprotective Effect of Ethanolic and Hydro Alcoholic Leaf Extract of Madhuca indica in Carbon Tetra Chloride Intoxicated Rat. Research J. Pharmacology and Pharmacodynamics. 2012; 4(5): 311-314.
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