Volume No. :   5

Issue No. :  1

Year :  2013

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Acute and Subacute Toxicity study of Milnacipran Hydrochloride in Wistar rats by Oral Route



Address:   D. Benito Johnson*, R. Suresh, Prakash Rao Prathima, R. Venkatnarayanan and Ashir Ahammad P.M
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Toxicity of a substance is nothing but unwanted or series of adverse events that was initiated after administration of particular chemical, physical or biological agent. Acute toxicity study aim is to determine the occurred toxic manifestation of the administered test substance after expose to animals in one or more doses for a period of 14 days. The study provides the information or determination of therapeutic index, i.e. T.I. = LD50/ ED 50. Sub-acute toxicity testing evaluates the toxic effects of drug on repeated exposure and also provides the information on delayed and cumulative effect of the chemicals on the tissues or other biochemical mechanisms Depression is one of the most common psychiatric disorders. The symptoms of depression are often subtle and unrecognized both by patients and by physicians. Major depression remains difficult to treat, despite the wide array of registered antidepressant. Milnacipran is indicated for the treatment of major depressive disorder and management of fibromyalgia. Milnacipran inhibits norepinephrine and serotonin reuptake in a 3:1 ratio, in practical use this means a balanced (equal) action upon both transmitter.
KEYWORDS:
Milancipran, Depression, Acute toxicity, Sub-acute toxicity
Cite:
D Benito Johnson, R Suresh, Prakash Rao Prathima, R Venkatnarayanan , Ashir Ahammad PM. Acute and Subacute Toxicity study of Milnacipran Hydrochloride in Wistar rats by Oral Route. Research J. Pharmacology and Pharmacodynamics. 2013; 5(1): 51-58.
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