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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Antihypertensive Drugs prescribed in West Indian Territories
Patel Hirenkumar R.
Patel Hirenkumar R.*
Ph.D. Research Scholar, Department of Pharmacy, JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu – 333001, Rajasthan, India
Management of hypertension in patients provides a significant challenge for healthcare professionals. It was convincingly demonstrated that lowering of blood pressure below what is recommended for patients with essential hypertension. The present study was done to find prescription trend in Indian cardiology and nephrology practice and its adherence to therapeutic guidelines. For present study, 120 patients having blood pressure greater or equal to 140/90 mm Hg and fulfilling inclusion-exclusion criteria were enrolled and data of Serum Creatinine and Blood Pressure were recorded at 0 week, 4 week, 8 week and 12 week. In treatment strategy, Goal of blood pressure is to achieve BP up to <130/80 mmHg for all patients. There is still controversy about effectiveness of antihypertensive drugs in CKD. In view of JNC VII guideline, ACE inhibitors should be used as first line treatment. It may surprising in this study that ACE inhibitors or Angiotensin receptor blockers were used only in 50% of the patients, whereas Diuretics were in 87% and Calcium channel blockers were prescribed in 73% patients. It was found that physicians hesitate to prescribe ACE inhibitors as first line treatment due to serious side effects such as brassy cough and hyperkalemia. It was concluded that there is still potential to increase the prescription frequency of ACE inhibitors and AT1 blockers. Management of Hypertension is more difficult in renal patients and requires multi drug therapy, which is further influenced adversely by diabetic condition.
Hypertension, ACE inhibitors, BP, CKD, AT1 blockers.
Patel Hirenkumar R. Antihypertensive Drugs prescribed in West Indian Territories. Research J. Pharmacology and Pharmacodynamics. 2013; 5(1): 75-79.
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