Volume No. :   5

Issue No. :  2

Year :  2013

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals



Address:   K. Sravanthi1*, K.V. Ramana2, G. Sumalatha1, K. Neeraja3
1Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India.
2Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India.
3Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid –induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant
KEYWORDS:
Analgesic, anti-inflammatory, Carrageenan, acute toxicity, Solanum surattense
Cite:
K Sravanthi, KV Ramana, G Sumalatha, K Neeraja Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals. Research J. Pharmacology and Pharmacodynamics. 2013; 5(2): 101-105
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