Volume No. :   5

Issue No. :  4

Year :  2013

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Evaluation of anti-depressant activity of Methanolic Seed Extract of Avena sativa L. In Mice



Address:   Praveen Kumar Uppala1*, Swarna Latha M.1, Shashidhar Reddy R.2, G. Chakravarthi3
1K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad.
2T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad.
3College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.
KEYWORDS:
Avena sativa, Antidepressant activity, Forced swim test, Tail suspension test, Antagonising apomorphine induced hypothermia.
Cite:
Praveen Kumar Uppala, Swarna Latha M, Shashidhar Reddy R, G Chakravarthi. Evaluation of anti-depressant activity of Methanolic Seed Extract of Avena sativa L. In Mice. Research J. Pharmacology and Pharmacodynamics. 2013; 5(4). 212-217.
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