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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Effect of Quisqualis indica extract on cholesterol diet induced hyperlipidemia in rats
Patel Pushpendra Kumar
Chanchal Deep Kaur .
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Sahu Jyoti1, Patel Pushpendra Kumar2, Chanchal Deep Kaur1*
1Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari (Durg), Chhattisgarh, India.
2Siddhi Vinayak Institute of Technology and Science, Bilaspur, India.
Treatment of hyperlipidemia is important for prevention of many disease especially coronary heart diseases. It has been proven that 20% of all strokes and over 50% of all heart attacks can be linked to high fatty substances (cholesterol) and it can be reduced by increased dietary intake of antioxidants which is a vast source of plant extracts. In the present study the hypolipidemic activity of methanolic extracts of aerial parts of Quisqualis indica (QI) including flowers on cholesterol diet (PS) induced hyperlipidemia in rats had been evaluated. Hyperlipidemia was induced by cholesterol diet (dry coconut, milk powder etc). The hypolipidemic activity was analyzed by reading the blood serum level in UV at 505 nm after treated with reagent present in auto span diagnostic kit. Dose of Methanolic extracts of QI had been prepared by using distilled water i.e. 100 mg/kg p.o and 200 mg/kg p.o. Methanolic extracts of QI significantly reduce the harmful lipid layer in blood serum at varying concentration which shows that the plant carries the hypolipidemic properties which was may be due to the inhibition of lipid peroxidation as the plants contain some active ingredients acting as antioxidants. Result shows that the plants extracts was more effective at 200 mg/kg whereas Atorvastatin (10mg/kg) drug is used as standard drug.
Hypolipidemic, Hypocholesterolemic, Cholesterol diet, Hyperlipidemia, Quisqualis indica, Coronary heart disease.
Sahu Jyoti, Patel Pushpendra Kumar, Chanchal Deep Kaur . Effect of Quisqualis indica extract on cholesterol diet induced hyperlipidemia in rats. Research J. Pharmacology and Pharmacodynamics. 2013; 5(6): 317-320 .
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