Volume No. :   7

Issue No. :  4

Year :  2015

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Experimental Evaluation of Antiepileptic Activity of Amalakyadi Ghrita



Address:   Kale Rupali C.1, Gadgil Swati S.2*, Borole Kanchan D.3, Wele Asmita A.4
1Ayurved Practitioner, Pune
2Assistant Professor, Department of Rasashastra Bhaishajyakalpana, College of Ayurved, Bharati Vidyapeeth Deemed University, Pune.
3Assistant Professor, Pharmacology Dept., Bharati Vidyapeeth Deemed University, Medical College, Pune.
4Professor and HOD, Department of Rasashastra Bhaishajyakalpana and Dean, Bharati Vidyapeeth Deemed University, College of Ayurved, Pune.
*Corresponding Author
DOI No: 10.5958/2321-5836.2015.00030.0

ABSTRACT:
Amalakyadi Ghrita (AG) a ghee based formulation is recommended for the treatment of Apasmar (Epilepsy) in Ayurved. Present study has been designed to prepare standard Amalakyadi Ghrita and evaluate it’s antiepileptic activity using animal models namely Maximal Electricshock Seizures (MES) and Pentelenetetrazole (PTZ) induced seizure. It has been prepared, standardised using analytical tests and subjected to preliminary phytochemical analysis. Control drug, i.e. Cow ghee 5gm/kg, Standard drug, i.e. Phenytoin 25mg/kg and AG at three dose levels 2.5gm/kg, 5gm/kg and 10gm/kg. were administered orally in all the models. Mean values and standard error of mean was determined for all models and data was analyzed by one-way ANOVA, followed by Dunnett’s test. Preliminary phytochemical analysis of AG showed presence of alkaloids, phenols, tannins and flavonoids. AG at medium and higher dose exhibited significant antiepileptic activity in MES model by decreasing the duration of tonic extensor phase (p<0.001). In PTZ model, AG at higher dose, significantly delayed the onset of convulsions (p<0.05). AG has shown significant anticonvulsant activity in both the study models. The presence of different phyto constituents in the formulation may singularly or in combination be responsible for this activity.
KEYWORDS:
Amalakyadi Ghrita, Antiepileptic Activity, Apasmar, Ayurved, MES, PTZ
Cite:
Kale Rupali C, Gadgil Swati S, Borole Kanchan D, Wele Asmita A . Experimental Evaluation of Antiepileptic Activity of Amalakyadi Ghrita. Research Journal of Pharmacology and Pharmacodynamics. 2015; 7(4): 155-160.
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