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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Deeper insights into Mechanism Based Drug Action: A Review
Ashish Kumar Netam
Ashish Kumar Netam*, Jhakeshwar Prasad, Trilochan Satapathy
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur -493111 Dist-Raipur (C.G.) India.
Pharmacodynamic is considered as a major branch of pharmacology that deals with the study about the drug or ligand as well as its biochemical and physiological effects including their mechanisms of action on living organisms.Most of the drugs combine with some molecular structure on the surface of the cell or within the cell. This molecular structure is called a receptorwhich is made up of proteins or proteinaceous materials.When drug molecule approaches the receptors for binding and such post binding drug-receptor complex can altered configuration or charge distribution, and thereby triggers a catalytic effect leading to a response. Many drugs that may be exogenous or endogenous such as hormones or transmitters that mimic the effects because they combine with the receptors and produce its effect via different mechanism. In this review our efforts have been devoted to represent the different signal transduction pathways involved to elicit pharmacological response.
Receptor, Mechanism, Drug action, signal transduction pathways.
Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy. Deeper insights into Mechanism Based Drug Action: A Review. Res. J. Pharmacology and Pharmacodynamics.2018; 10(1): 17-23.
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