Volume No. :   10

Issue No. :  1

Year :  2018

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Structural Architecture and Signal Transduction of Ion Channels: A Review



Address:   Mahendra Kumar Sahu*, Trilochan Satapathy, Ashish Kumar Netam, Jhakeshwar Prasad
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur -493111Dist-Raipur (C.G.) India.
*Corresponding Author
DOI No: 10.5958/2321-5836.2018.00007.1

ABSTRACT:
Ions are small charged molecules they have ability to produce signals to exert the pharmacological response. The ions which are mostly carried in physiological conditions are free atoms in solution typically sodium, potassium, calcium and chlorides. Once an ion has permeated or exited the cell, it not only changes its electrical membrane potential, but alsochanges several ions, particularly calcium, is used as messengers within the cell, and can regulate many complicated and long lasting catalytic effects of the cell. Ion channels are made up off glycoprotein (protein with sugar molecules attached) that transverse the cell membrane. They are formed by aggregation of subunits, each a protein by itself, into a cylindrical configuration that allows a pore, thus forming a kind of tube. Ions permeate through their specific channels by electrical potential or differences in concentration gradient across the cell membrane. In this review we have tried to describe the details about the various types of ion channels such as ligand gated ion channels voltage gated channels etc and their signal transduction mechanism for evoke the biological activity.
KEYWORDS:
Ion channel, Ligand gated, Voltage gated, subunits, Response.
Cite:
Mahendra Kumar Sahu, Trilochan Satapathy, Ashish Kumar Netam, Jhakeshwar Prasad. Structural Architecture and Signal Transduction of Ion Channels: A Review. Res. J. Pharmacology and Pharmacodynamics.2018; 10(1): 38-44.
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