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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Hydro alcoholic extract of Punica granatum for anthelmintic activity
Syed Ibrahim, Mohammed Abrar, Roshan S*
Deccan School of Pharmacy, Aghapura, Hyderabad-01, India.
The present study was aimed to investigate the anthelmintic potential of Hydro alcoholic Punica granatum Peel extract on Indian earth-worm Pheretima posthuma. Three concentrations (100, 150, 200 mg/ml) of extract were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Albendazole (20 mg/ml) in same concentration as those of extract was included as standard reference and normal saline water with 0.5 % w/v CMC as control. The extracts exhibited significant anthelmintic activity at a concentration of 150,200 mg/ml. Peak activity was exhibited by the Hydro alcoholic extract at a concentration of 200 mg/ml, respectively dose-dependent action and inhibition of spontaneous motility (paralysis) and death of earthworms Findings of the present investigations confirms that, the ethno-medicinal claim of anthelmintic activity of this plant is genuine.
Punica granatum, Anthelmintic activity, Albendazole, Vermifuge, Vermicidal.
Syed Ibrahim, Mohammed Abrar, Roshan S. Hydro alcoholic extract of Punica granatum for anthelmintic activity. Res. J. Pharmacology and Pharmacodynamics.2018; 10(2): 66-68.
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