Volume No. :   10

Issue No. :  2

Year :  2018

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Hydro alcoholic extract of Punica granatum for anthelmintic activity



Address:   Syed Ibrahim, Mohammed Abrar, Roshan S*
Deccan School of Pharmacy, Aghapura, Hyderabad-01, India.
*Corresponding Author
DOI No: 10.5958/2321-5836.2018.00011.3

ABSTRACT:
The present study was aimed to investigate the anthelmintic potential of Hydro alcoholic Punica granatum Peel extract on Indian earth-worm Pheretima posthuma. Three concentrations (100, 150, 200 mg/ml) of extract were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Albendazole (20 mg/ml) in same concentration as those of extract was included as standard reference and normal saline water with 0.5 % w/v CMC as control. The extracts exhibited significant anthelmintic activity at a concentration of 150,200 mg/ml. Peak activity was exhibited by the Hydro alcoholic extract at a concentration of 200 mg/ml, respectively dose-dependent action and inhibition of spontaneous motility (paralysis) and death of earthworms Findings of the present investigations confirms that, the ethno-medicinal claim of anthelmintic activity of this plant is genuine.
KEYWORDS:
Punica granatum, Anthelmintic activity, Albendazole, Vermifuge, Vermicidal.
Cite:
Syed Ibrahim, Mohammed Abrar, Roshan S. Hydro alcoholic extract of Punica granatum for anthelmintic activity. Res. J. Pharmacology and Pharmacodynamics.2018; 10(2): 66-68.
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