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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Detrimental effects of Sulphur Dioxide Gas on Liver Parameters and its Modulation by Aloe Vera
Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B. R. Ambedkar University, Agra
Air pollution has become a serious environmental issue and a threat to all over the world. SO2 is considered as the most poisonous and irritant gas as it penetrates deeper in the vitals hence alters the physiology, biochemistry and behavior of the living individuals. The present study has been designed to explore out the protective effect of Aloe vera against SO2 induced hepatotoxicity in albino rats. The twenty albino rats were grouped in four sets-control set (1) were kept in control conditions, while, experimental set (2) was exposed to 80ppm of SO2 gas 1h/d for 30 and 60 days, experimental set (3) were exposed to 80ppm of SO2 gas 1h/d with oral administration of Aloe vera fruits extracts (200mg/kg b.wt.) for 30 and 60 days respectively. The findings of the present investigation have indicated that SO2 causes significant increase in total bilirubin (p<0.05), conjugated bilirubin (p<0.05) but non-significant increase in unconjugated bilirubin level in liver as well as significant decrease in serum total protein (p<0.001), serum albumin (p<0.05), globulin (p<0.05), besides, significant increase in serum enzymes AST(p<0.01), ALT(p<0.001), GGT(p<0.01) and ALP (p<0.001) in liver of albino rats. Oral administration of Aloe vera recovers all these alterations at their normal level which is an indication of remedial effect of A. vera on SO2 induced hepatotoxicity.
Albino rats, SO2, A. vera, Serum Bilirubins, Total Protein, Serum enzymes.
Madhuri Yadav. Detrimental effects of Sulphur Dioxide Gas on Liver Parameters and its Modulation by Aloe Vera. Res. J. Pharmacology & Pharmacodynamics.2018; 10(4): 149-155.
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