Volume No. :   10

Issue No. :  4

Year :  2018

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Influence of dietary substances on recognition memory in Albino mice



Address:   Kadiri Sunil Kumar1, R. Suthakaran2, Ravindar Bairam3
1,2Department of Pharmacology and Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor 501511, Hyderabad, Telangana, India
3Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Sciences, Near Ramoji Film City, Deshmukhi, Nalgonda, Telangana State-50828, India
*Corresponding Author
DOI No: 10.5958/2321-5836.2018.00028.9

ABSTRACT:
The present investigation was designed to evaluate the effects of dietary substances such as Saccharin (100 mg/kg, p.o), Turmeric (1g/kg, p.o) and Transfat (2%, p.o) on recognition memory in albino mice by employing Y maze test. The test mice were treated with the above dietary substances for a period of 30 days. Control mice received distilled water, p.o for 30 days. Standard mice received cerebroactive drug Donepezil (1mg/kg, p.o) for 30 days. The assessment of memory commences on 31st day by placing each mouse in the centre of the Y maze apparatus for 5 minutes and the memory parameters like spontaneous alteration performance (SAP), alternate arm return (AAR) and same arm return (SAR) were recorded. SAP which is a measure of memory was found to be lower with transfat (15±0.01) and saccharin (14±1.21) when compared to control mice (20±0.12) indicating loss of memory with transfat and saccharin. Turmeric treated mice displayed a significant increase in SAP (30±0.75) than the control mice indicating memory enhancing potential of turmeric. However SAP of donepezil treated mice was found to be more (34±0.04) than the turmeric treated mice.
KEYWORDS:
Recognition memory, saccharin, turmeric, transfat, Donepezil, SAP.
Cite:
Kadiri Sunil Kumar, R. Suthakaran, Ravindar Bairam. Influence of dietary substances on recognition memory in Albino mice. Res. J. Pharmacology & Pharmacodynamics.2018; 10(4): 156-158.
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