Volume No. :   11

Issue No. :  1

Year :  2019

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Evaluation of Anti-ulcer activity of Ethyl acetate extract of Azima tetracantha Lam in Experimental rats



Address:   B. Edwin Jose1, Dr. P. Muralidharan2, P. Arunmozhivarman3*, B. Chandrakala4, S. Arunkumar5, S. S. Arunkumar6
1Department of Pharmaceutical Chemistry, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi
2Department of Pharmacology, C. L. Biad Metha College of Pharmacy, Chennai
3,4,5,6Department of Pharmaceutical Chemistry, SSM College of pharmacy, Erode
*Corresponding Author
DOI No: 10.5958/2321-5836.2019.00006.5

ABSTRACT:
The anti-ulcer activity of ethyl acetate extract of Azima tetracantha Lam (Salvadoraceae) was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. Ethyl acetate extract of Azima tetracantha Lam at doses of 250,500 mg/kg p.o produced significant inhibition of the gastric lesions induced by Pylorus ligation induced ulcer and Ethanol induced gastric ulcer .The extract (250 mg/kg and 500 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Azima tetracantha Lam extract have potential anti ulcer activity in the both models. These results may further suggest that ethyl acetate extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
KEYWORDS:
Azima tetracantha Lam, Pylorus ligation, Ethanol induced ulcer model, ulcer index.
Cite:
B. Edwin Jose, P. Muralidharan, P. Arunmozhivarman, B. Chandrakala, S. Arunkumar, S. S. Arunkumar. Evaluation of Anti-ulcer activity of Ethyl acetate extract of Azima tetracantha Lam in Experimental rats. Res. J. Pharmacology and Pharmacodynamics.2019; 11(1):27-31.
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