Volume No. :   11

Issue No. :  3

Year :  2019

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Pharmacological Evaluation of Livodac Tablet on Paracetamol induced Hepatotoxicity Models in Wistar rats



Address:   Pradnya. N. Jagtap1*, Prachali Ramdas Chavan2
1Pune District Education Association’s, Seth Govind Raghunath Sable College of Pharmacy, Saswad 412301, Tal. Purandar, Dist. Pune, Maharashtra, India.
2M. Pharm (Pharmacology Department), Pune District Education Association’s, Seth Govind Raghunath Sable College of Pharmacy, Saswad 412301, Tal. Purandar, Dist. Pune, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/2321-5836.2019.00014.4

ABSTRACT:
The present study was conducted to evaluate the Hepatoprotective activity of livodac tablet against Paracetamol induced liver cirrhosis in Wistar rats. The livodac tablet (100, 200 and 400mg/kg) was administered orally to the animals with hepatotoxicity induced by Paracetamol (2gm/kg). Silyamarin (54mg/kg) was given as reference standard. The livodac tablet was effective in protecting the liver against the hepatotoxicity induced by Paracetamol in rats. This was evident from significant reduction in serum enzymes alkaline phosphate, total Bilirubin, total protein, serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT). It was concluded from the result the livodac tablet was Hepatoprotective activity against Paracetamol induced hepatotoxicity in rats.
KEYWORDS:
Livodac Tablet, Paracetamol, Hepatoprotectiveand Hepatotoxicity.
Cite:
Pradnya. N. Jagtap, Prachali Ramdas Chavan. Pharmacological Evaluation of Livodac Tablet on Paracetamol induced Hepatotoxicity Models in Wistar rats. Res. J. Pharmacology and Pharmacodynamics.2019; 11(3): 83-88.
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