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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Stupendous aspect of Endorphins in Curtailiing Stress and Migraine
Mebin T, Mohamed Thoufiq*, Sambathkumar R
Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy Kumarapalayam – 638183, Tamil Nadu, India
Background: There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including migraine. However, what exact aspect of exercise plays in migraine prevention is unclear. Based on latest clinical research, this paper will review briefly the stupendous aspect of endorphins in curtailing migraine and stress. Methods: The review was based on a primary literature search on the PubMed using the search terms “migraine and exercise”. Results: Low levels of physical exercise and high frequency of migraine has been reported in several large population-based studies. In experimental studies exercise has been reported as a trigger factor for migraine as well as migraine prophylaxis. Possible mechanisms for how exercise may trigger migraine attacks, include acute release of neuropeptides such as calcitonin gene-related peptide or alternation of hypocretin or lactate metabolism. Mechanisms for migraine prevention by exercise may include increased beta-endorphin, endocannabinoid and brain-derived neurotrophic factor levers in plasma after exercise. Conclusion: Exercise can be used for management of several chronic pain conditions. Interestingly, this includes conditions comorbid with migraine such as depression, anxiety and sleep disturbances. Moreover, exercise has been shown to improve self-esteem which is also associated with alleviating symptoms of migraine.
Migraine pathophysiology, Migraine treatment, Stress management, Exercise and sexual intercourse.
Mebin T, Mohamed Thoufiq, Sambathkumar R. Stupendous aspect of Endorphins in Curtailiing Stress and Migraine. Res. J. Pharmacology and Pharmacodynamics.2020; 12(1):25-28.
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