ABSTRACT:
The antidiabetic activity of ethanolic fresh leaf extracts of Cichorium intybus, Gymnema sylvestre, Aegle marmelos in alloxan induced diabetic rats. Alloxan induced diabetic in rats (n=6) were administered ethanolic fresh leaf extracts of Cichorium intybus (0.25g/Kg), Gymnema sylvestre (0.25g/Kg) , Aegle marmelos (0.25g/Kg) and standard drug Glibenclamide (0.07g/Kg) for 7 days. On eight day of the treatment , blood samples were collected by puncturing the retro-orbital plexus under mild ether anesthesia and kept aside for ½ h for clotting. Blood glucose levels were determined by glucose oxidase method. Serum was separated by centrifuging the samples for 20 mins and stored in the refrigerator. The serum was analyzed for blood glucose level, total protein, cholesterol and triglycerides .These three medicinal plants of alcoholic extracts shown significant (P<0.05) reduction in blood glucose level. However, Cichorium intybus leaf extracts was highly effective and results are comparable with that of reference drug, glibenclamide. Diabetic animals treated with these three leaf alcoholic extracts shown significant (P<0.05) effect on serum protein, cholesterol and triglyceride level. In comparison to other extracts Cichorium intybus alcoholic leaf extract fraction was found to be more potent in normalizing the blood lipids and protein level in Alloxan induced diabetic rats. It is concluded that Cichorium intybus, Gymnema sylvestre and Aegle marmelos has significant antidiabetic activity as it lowers the blood glucose levels in diabetic rats and increases the glucose tolerance.