Author(s): IJ Kuppast, P Vasudeva Nayak, MC Ravi, SS Biradar.

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Address: IJ Kuppast1, P Vasudeva Nayak2, MC Ravi1 and SS Biradar3.
1Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shimoga-577 202 Karnataka, India.
2Department of Studies in Chemistry, Kuvempu University, Jnana Sahyadri, Shankarghatta, Shimoga-577 451 Karnataka, India.
3Department of Pharmaceutics, H.K.E College of Pharmacy, Gulberga, Karnataka, India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2009

In the present study anti-anaemic effect of the petroleum ether, solvent ether, ethyl acetate, butanol and butanon extracts of Cordia dichotoma Forst.f. fruits was evaluated in albino rats. The rats were made anaemic as per standard procedure and were treated daily by extracts in the dose of 100, 200 and 300 mg/kg body weight for 15 days p.o. After 15 days of daily treatment with the extracts of fruits, the haematological parameters measured are clotting time, bleeding time, hemoglobin content, total count of red blood corpuscles, white blood cells and differential count of leucocytes. From the statistical analysis of the study it has been found that ethyl acetate, butanol and butanon extract of C. dichotoma fruits causes significant dose dependent rise in hemoglobin content and RBC count. However, reduction in clotting and bleeding time was not found to be dose dependent. The WBC count was found to rise only in higher doses of extracts (300mg). In case of higher doses (200 and 300mg/kg body weight) the extracts of fruits reduced the clotting and bleeding time, where as lower dose (100 mg/kg body weight) there was no significant change in bleeding and clotting time. The results suggest that the extracts of C. dichotoma fruits have significant ant-anaemic effect and are haematologically non toxic.

Cite this article:
IJ Kuppast, P Vasudeva Nayak, MC Ravi, SS Biradar. Studies on the Hematological Effect of the Extracts of Cordia dichotoma Forst. F. Fruits. Research J. Pharmacology and Pharmacodynamics. 2009; 1(3) Nov - Dec. 117-119.

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