Inflammation is the reaction of vascular connective tissue to local injury. Acute inflammation is immediate and early response to an injurious agent and its major components are vascular events. Inflammatory Mediators like histamine, cytokines, arachidonic acid metabolites, eicosanoids prostaglandins, leukotrienes, omega-3 polyunsaturated fatty acids, platelet-activating factor, Plasma proteins.Nitric Oxide plays a major role in causation of events. Currently NSAIDS and steroids control inflammation by targeting of cellular events they prevents inflammation. iNOS ( Inducible nitric oxide synthatase ) is involved in the synthesis of NO is induced whenever inflammatory cells are activated by cytokines. E.g.: TNF-a NO inactivates by anti proteases such as antitrypsin, decreases destruction of extra vascular matrix, inhibits iNOS and posses anti-inflammatory by Diazepam. Diazepam binds with peripheral benzodiazepapine receptors in macrophases and endothelial cells to inhibit iNOS and reduce the inflammation. It acting on neutrophills, monocytes and other inflammatory cells. It also inhibits diapedesis and chromo toxins of the cells towards inflammatory stimulus.It also inhibits cytokine secretion by the cells in adrenal cortex it increases the synthesis and release of endogenous glucocortocoid cortisol. The present study data support that the Carrageenan may act collaboratively to elicit inflammation leads to rise in paw volume. We compared the change in paw volume, pawlicking, paw score of aceclofenac sodium, diazepam, combination groups with respect to positive control group. Diazepam(4mg/kg) had better anti inflammatory activity compared to aceclofenac sodium. However combination of diazepam and Aceclofenac sodium did not produce any additive/synergistic effect.
Cite this article:
Narlapati. Jagadeesh. Effect and Comparison of Aceclofenac Sodium and Diazepam against Carrageenan Induced Inflammation in Swiss Albino mice. Res. J. Pharmacology and Pharmacodynamics.2018; 10(2): 61-65. doi: 10.5958/2321-5836.2018.00010.1