Author(s): O. Sreenivasa Krishna, S. Naveen Kumar, K. Vijay Kumar, C. Rajeswari4, CH. Akhil

Email(s): krishna.vlcp@gmail.com

DOI: 10.52711/2321-5836.2023.00019   

Address: O. Sreenivasa Krishna1, S. Naveen Kumar2, K. Vijay Kumar3, C. Rajeswari4, CH. Akhil5
1Assistant Professor, Department of Pharmacology, Jntua Oil Technological and Pharmaceutical Research Institute, Anantapur.
2,4M. Pharm Students, Department of Pharmacology JNTUA-OTPRI Anantapur, India.
3,5M. Pharm Students, Department of Pharmaceutical Chemistry JNTUA-OTPRI Anantapur India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2023


ABSTRACT:
Phytochemicals are known to contain a high concentration of therapeutically active principles, which, when consumed in sufficient quantities, can have drug-like effects. Bryophillum pinnatum (Lam.) is a succulent-ethno medicinal xerophyte with a long history of use in traditional Indian medicine. Because reactive oxygen species are the most common etiological factor in many degenerative diseases, controlling them with antioxidants may both treat and prevent disease progression. The current study will look at the ability of fresh leaf juice of Bryophillum pinnatum (Lam.) (FLJBP) to prevent oxidative injury and subsequent hemolysis in goat erythrocytes as a model test system. The catalytic activity of membrane bound enzymes like sodium potassium-ATPase, Ach-Ease, and metabolic enzymes like hexokinase, as well as the NO concentration in goat RBCs, were measured. Phenyl hydrazine was used first, followed by FLJBP at concentrations of 20, 40, 60, 80, and 100g/ml. A dose-dependent (PHZ) increase in Pi liberation by hexokinase and Na+/K+ ATPase, as well as increased formation of thiocholine iodide and enhanced NO scavenging potential, has indicated that flip has good anti-oxidant and anti-haemolytic activity. To record the functional food status of Bryophillum pinnatum (Lam.) species, a more rigorous and stringent battery of pharmacological, phytochemical, and bio analytical studies, followed by observational studies in humans, will be conducted.


Cite this article:
O. Sreenivasa Krishna, S. Naveen Kumar, K. Vijay Kumar, C. Rajeswari4, CH. Akhil. Evaluation of In-vitro Antioxidant Potential of Bryophillum pinnatum Leaf Juice in Phenyl Hydrazine Treated Goat Erythrocytes. Research Journal of Pharmacology and Pharmacodynamics. 2023; 15(3):103-8. doi: 10.52711/2321-5836.2023.00019

Cite(Electronic):
O. Sreenivasa Krishna, S. Naveen Kumar, K. Vijay Kumar, C. Rajeswari4, CH. Akhil. Evaluation of In-vitro Antioxidant Potential of Bryophillum pinnatum Leaf Juice in Phenyl Hydrazine Treated Goat Erythrocytes. Research Journal of Pharmacology and Pharmacodynamics. 2023; 15(3):103-8. doi: 10.52711/2321-5836.2023.00019   Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-3-2


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