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Research Journal of Pharmacology and Pharmacodynamics
ISSN: 2321-5836(Online), 0975-4407(Print)
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Anti Diabetic Activity of Sida cordifolia Linn of Nilgiris Root on Alloxan Induced Diabetic Rats
T Prabhakar*, PKM Nagarathna1 and BS Vikram1
Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64.
The aim of the present study was to screen the antidiabetic potential of the root of Sida cordifolia linn. In the present study, root of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600 c), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.
Sida cordifolia, anti diabetic, Glibenclamide, Alloxan.
T Prabhakar, PKM Nagarathna, BS Vikram. Anti Diabetic Activity of Sida cordifolia Linn of Nilgiris Root on Alloxan Induced Diabetic Rats. Research J. Pharmacology and Pharmacodynamics. 2009; 1(3):125-127.
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