Author(s): M Lavanya, Asish Bhaumik, A Gopi Reddy, Ch Manasa, B Kalyani, S Sushmitha

Email(s): Email ID Not Available

DOI: 10.5958/2321-5836.2016.00012.4   

Address: M. Lavanya1, Asish Bhaumik2*, A. Gopi Reddy3, Ch. Manasa1, B. Kalyani1, S. Sushmitha1
1,2Department of Pharmaceutical Chemistry, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana State, India.
3Department of Pharmaceutical Chemistry, SANA College of Pharmacy, Kodad, Nalgonda-508206, Telangana State, India.
*Corresponding Author

Published In:   Volume - 8,      Issue - 2,     Year - 2016


ABSTRACT:
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene. Growth of MCF7 cells is inhibited by tumor necrosis factor alpha (TNF alpha). Secretion of IGFBP's can be modulated by treatment with anti-estrogens. PIK3CA helical mutations were identified in MCF-7, but with low AKT activation. The main objective of the present research work is to isolate the bioactive molecules and evaluate the in vitro anticancer activity of ethanolic and ethyl acetoacetate extracts of sweet cherry (EEC and EAAEC) of Prunus avium. The in vitro anticancer activity was carried out against human breast cancer cell line MCF-7 by MTT assay. The results obtained from the in-vitro studies performed by MTT assay by using human breast cancer cell line MCF-7 displayed that the various extracts of sweet cherry (EEC and EAAEC) possessed a very good anticancer activity. From the present studied it had been concluded that EEC and EAAEC, all were exhibiting the potential capability to inhibit the cancer cell when compared with standard drug doxorubicin and the cell growth inhibition of EEC and EAAEC was found to be the highest 92.90% growth inhibition at 10 µg (IC50 = 2.4 µg/ml) and EAAEC with the 92.49% growth inhibition at 10 µg (IC50 = 2.9 µg/ml).


Cite this article:
M Lavanya, Asish Bhaumik, A Gopi Reddy, Ch Manasa, B Kalyani, S Sushmitha. Evaluation of Anticancer Activity of Ethanolic and Ethylacetoacetate Extracts of Sweet Cherry Against Human Breast Cancer Cell Line MCF-7. Research J. Pharmacology & Pharmacodynamics.2016; 8(2): 65-70 doi: 10.5958/2321-5836.2016.00012.4


Recomonded Articles:

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): Manasa K.S, Kuppast I.J, Kishan Kumar M.A , Akshara K

DOI: 10.5958/2321-5836.2016.00034.3         Access: Open Access Read More

Author(s): M Lavanya, Asish Bhaumik, A Gopi Reddy, Ch Manasa, B Kalyani, S Sushmitha

DOI: 10.5958/2321-5836.2016.00012.4         Access: Open Access Read More

Author(s): Ajay Kumar Meena, Himanshu Sehgal, MM Rao, P Panda, MM Padhi.

DOI: Not Available         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Bikartana Das, GC Bhuyan, Abhijit Joshi MM Rao.

DOI: 10.5958/2321-5836.2015.00027.0         Access: Open Access Read More

Author(s): Swati Patil, S R Naik, V Joshi, CI Jolly, S Narayanan.

DOI: Not Available         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/2321-5836.2017.00017.9         Access: Open Access Read More

Author(s): Prakash S. Sukhramani, Piyush M Patel.

DOI: Not Available         Access: Open Access Read More

Author(s): DK Suresh, Mangesh Gavali, Vivek Ingale, Bhaumik Thakar, Md. Saifuddin K, Raghvendra Rao.

DOI: Not Available         Access: Open Access Read More

Author(s): Qureshi Md. Shamim, Patel Jitendra, Venkateshwar Reddy A, Syed Safiullah, P Mohapatra.

DOI: Not Available         Access: Open Access Read More

Author(s): Syed Sagheer Ahmed, Chandra Prakash. K, Saba Tabassum, Noor Salma, Ahalya Devi. K H

DOI: 10.5958/2321-5836.2019.00003.X         Access: Closed Access Read More

Author(s): Dubey R D, Ahmad A R, Paroha S, Sahu P K, Verma S, Daharwal S J, Prasad Reddy S L N, Qureshi M S.

DOI: Not Available         Access: Open Access Read More

Author(s): Prakash S. Sukhramani, Piyush M Patel.

DOI: Not Available         Access: Open Access Read More

Author(s): Rupali Kirtawade, Pallavi Salve, Chhotaram Seervi, Anita Kulkarni and Pandurang Dhabale.

DOI: Not Available         Access: Open Access Read More

Author(s): Jisha K, Venkateswaramurthy N, Sambathkumar R

DOI: 10.5958/2321-5836.2020.00007.5         Access: Closed Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags