Author(s):
Ganesh G. Dhakad, Bhagyashri O. Fate, Amruta R. Pandav, Abhijit V. Shrirao, N. I. Kochar, A. V. Chandewar
Email(s):
ganeshdhakad552@gmail.com
DOI:
10.52711/2321-5836.2023.00016
Address:
Ganesh G. Dhakad, Bhagyashri O. Fate, Amruta R. Pandav, Abhijit V. Shrirao, N. I. Kochar, A. V. Chandewar
PataldhamalWadhwani College of Pharmacy, Yavatmal.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2023
ABSTRACT:
Stem cells have the ability to differentiate into specific cell types. The two defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type. There are two major classes of stem cells: pluripotent that can become any cell in the adult body, and multipotent that are restricted to becoming a more limited population of cells. Cell sources, characteristics, differentiation and therapeutic applications are discussed. Stem cells have great potential in tissue regeneration and repair but much still needs to be learned about their biology, manipulation and safety before their full therapeutic potential can be achieved.
Cite this article:
Ganesh G. Dhakad, Bhagyashri O. Fate, Amruta R. Pandav, Abhijit V. Shrirao, N. I. Kochar, A. V. Chandewar. Review on Stem Cell Therapy and its Various Aspects. Research Journal of Pharmacology and Pharmacodynamics.2023;15(2):77-6. doi: 10.52711/2321-5836.2023.00016
Cite(Electronic):
Ganesh G. Dhakad, Bhagyashri O. Fate, Amruta R. Pandav, Abhijit V. Shrirao, N. I. Kochar, A. V. Chandewar. Review on Stem Cell Therapy and its Various Aspects. Research Journal of Pharmacology and Pharmacodynamics.2023;15(2):77-6. doi: 10.52711/2321-5836.2023.00016 Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-2-8
REFERENCE:
1. National Institutes of Health resource for stem cell research. [July 21, 2008]; the stem cell information Stem Cell Basics page. Available at: http://stemcells.nih.gov/info/basics/defaultpage.asp.
2. Bajada S, Mazakova I, Richardson JB, Ashammakhi N. Updates on stem cells and their application in regenerative medicine. J Tissue Eng Regen Med. 2008; 2(4):169–83. [PubMed] [Google Scholar]
3. Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. CurrOpin Cell Biol. 2004; 16(6):700–7. [PubMed] [Google Scholar]
4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663–76. [PubMed] [Google Scholar]
5. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861–72. [PubMed] [Google Scholar]
6. Yu J, Vodyanik M, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318(5858):1917–20. [PubMed] [Google Scholar]. Park IH, Zhao R, West JA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008; 451(7175):141–6. [PubMed] [Google Scholar]
7. Aoi T, Yae K, Nakagawa M, et al. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science. 2008 Epub ahead of print. [PubMed] [Google Scholar]
8. Nakagawa M, Koyanagi M, Tanabe K, et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotech. 2008; 26(1):101–106. [PubMed] [Google Scholar]
9. Good RA, Meuwissen HJ, Hong R, Gatti RA. Bone marrow transplantation: correction of immune deficit in lymphopenic immunologic deficiency and correction of an immunologically induced pancytopenia. Trans Assoc AM Physicians. 1969; 82:278–85. [PubMed] [Google Scholar]
10. Kogler F, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med. 2004; 200(2):123–35. [PMC free article] [PubMed] [Google Scholar]
11. Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003; 114(6):763–76. [PubMed] [Google Scholar]
12. Greenfield JP, Ayuso-Sacido A, Schwartz TH, et al. Use of human neural tissue for the generation of progenitors. Neurosurgery. 2008; 62(1):21–37. [PubMed] [Google Scholar]
13. Wobus AM. Potential of embryonic stem cells. Mol Aspects Med. 2001; 22:149–64. [PubMed] [Google Scholar]
14. Yamanaka S, Jinliang Li, Kania G, et al. Pluripotency of embryonic stem cells. Cell Tissue Res. 2008; 331:5–22. [PubMed] [Google Scholar]
15. National Institutes of Health resource for stem cell research. [May 28, 2008]; The stem cell information appendix C page. Available at: http://stemcells.nih.gov/info/scireport/appendixC.asp.
16. Yang L, Soonpaa MH, Adler ED, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008; 453(7194):524–8. [PubMed] [Google Scholar]
17. Laflamme MA, Chen KY, Naumova AV, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infracted rat hearts. Nat Biotechnol. 2007; 25(9):1015–24. [PubMed] [Google Scholar]
18. Zhuo BH, Li TY, Jiang HB, Qu P, Liu Y. The effect of all-trans retinoic acid on the differentiation of marrow stromal stem cells into neurons. ActaNutrimentaSinica. 2005; 27(3):189–92. [Google Scholar]
19. Li TS, Komota T, Ohshima M, et al. TGF-β induces the differentiation of bone marrow stem cells into immature cardiomyocytes. BiochemBiophys Res Commun. 2008; 366:1074–80. [PubMed] [Google Scholar]
20. Hsieh, P. C. et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Med.13, 970–974 (2007).
21. Poss, K. D., Wilson, L. G. and Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188–2190 (2002).
22. Heber-Katz, E. et al. The scarless heart and the MRL mouse. Phil. Trans. R. Soc. B 359, 785–793 (2004).
23. Haris Naseem, R. et al. Reparative myocardial mechanisms in adult C57BL/6 and MRL mice following injury. Physiol. Genomics 30, 44–52 (2007).
24. Wollert, K. C. and Drexler, H. Clinical applications of stem cells for the heart. Circ. Res. 96, 151–163 (2005).
25. . Menasche, P. Skeletal myoblasts as a therapeutic agent. Prog. Cardiovasc. Dis. 50, 7–17 (2007).
26. Cleland, J. G. et al. Clinical trials update from the American Heart Association 2006: OAT, SALT 1 and 2, MAGIC, ABCD, PABA-CHF, IMPROVE-CHF, and percutaneous mitral annuloplasty. Eur. J. Heart Fail. 9, 92–97 (2007)
27. Winitsky, S. O. et al. Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol. 3, e87 (2005).
28. Leri, A., Kajstura, J. and Anversa, P. Cardiac stem cells and mechanisms of myocardial regeneration. Physiol. Rev. 85, 1373–1416 (2005). This is a comprehensive review of CSCs.
29. Quaini, F. et al. Chimerism of the transplanted heart. N. Engl. J. Med. 346, 5–15 (2002).
30. Jackson, K. A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest.107, 1395–1402 (2001). This classic study reveals the participation of bone-marrow-derived stem cells in cardiac regeneration
31. Steece-Collier, K. et al. Embryonic mesencephalic grafts increase levodopainduced forelimb hyperkinesia in parkinsonian rats. Mov. Disord. 18, 1442–1454 (2003).
32. Björklund, L.M. et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA 99, 2344–2349 (2002).
33. Erdö, F. et al. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J. Cereb. Blood Flow Metab. 23, 780–785 (2003).
34. Kondziolka, D. et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55, 565–569 (2000).
35. Meltzer, C.C. et al. Serial [18F]fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke. Neurosurgery 49, 586–591 (2001).
36. Nelson, P.T. et al. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. Am. J. Pathol. 160, 1201–1206 (2002).
37. Alvarez-Dolado, M. et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968–973 (2003).
38. Weimann, J.M., Johansson, C.B., Trejo, A. and Blau, H.M. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat. Cell Biol. 5, 959–966 (2003).
39. Parent, J.M., Vexler, Z.S., Gong, C., Derugin, N. and Ferriero, D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol. 52, 802–813 (2002).
40. Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z. and Lindvall, O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963–970 (2002).
41. Jin, K. et al. Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol. Cell Neurosci. 24, 171–189 (2003)
42. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specifications. Cell. 2006; 126(4):677–89. [PubMed] [Google Scholar]
43. Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with parkinson’s disease. Proc Natl Acad Sci USA. 2008; 105(15):5856–61. [PMC free article] [PubMed] [Google Scholar]