Author(s):
Narjis Fatma, Lalit Parihar, Anshika Garg
Email(s):
Email ID Not Available
DOI:
10.52711/2321-5836.2025.00030 
Address:
Narjis Fatma1, Lalit Parihar2, Anshika Garg3
1RV Northland Institute, Dadri, Uttar Pradesh, India.
2Sanskar College of Pharmacy and Research, Ghaziabad, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 3,
Year - 2025
ABSTRACT:
Despite many advances in medical intervention, cardiov?scular dise?ses (CVD) are the leading cause of death worldwide. Among them, the is?hemi? he?rt dise?ses, especially the ?cute my???rdi?l inf?rction (MI), ?re present in all of the most h?rrifi? v?lues. The present investigation aimed to evaluate the cardioprotective effect of Acacia arabica extract against Isoproterenol-induced myocardial infarction in rats. ?. ar?bi?? (100mg/kg ?nd 200mg/kg, p.o) was given to rats for 15 days. On the 14th and 15th days, MI was induced by a single dose of Isoproterenol (200mg/ kg, s.c.). Serum and heart tissues were collected at the conclusion of the experiment (i.e., on day 16), and total cholesterol (T), high density lipoprotein (HDL), triglyceride, and malondialdehyde, superoxide dismutase, catalase (T), redu?ed glut?thione (GSH), and body weight were measured. ?dministr?ti?n ?f Isoproterenol in ??ntr?l r?ts sh?wed ? signifi??nt (?<0.001) in?re?se in serum ?h?lester?l ?l?nine tr?ns?min?se (?LT), ?s??rt?te ?min?tr?nsfer?se (?ST), ?lk?line ?h?s?h?t?se (?L?) ?nd l?w-density li???r?tein (LDL). There w?s ? signifi??nt in?re?se (?<0.01) in the levels ?f he?rt tissues ?s ??m??red with res?e?tive ??ntr?l gr?u?s. R?ts tre?ted by ?. ar?bi?? signifi??ntly (?<0.01) de?re?sed ?LT, ?ST, ?L?, LDL, ?nd T?. M?re?ver, there w?s ?n in?re?sed ??T ?nd GSH levels in r?t tre?ted with ?. ar?bi??, when compared to the control group. In experimentally induced MI in rats, A. arabica (100 and 200mg/kg p.m.) is effective in controlling blood LDL levels and reducing cardiac complications.
Cite this article:
Narjis Fatma, Lalit Parihar, Anshika Garg. Investigating the Cardioprotective effect of Acacia arabica extract in Isoproterenol-induced Myocardial Infarction in Rats. Research Journal of Pharmacology and Pharmacodynamics.2025;17(3):181-7. doi: 10.52711/2321-5836.2025.00030
Cite(Electronic):
Narjis Fatma, Lalit Parihar, Anshika Garg. Investigating the Cardioprotective effect of Acacia arabica extract in Isoproterenol-induced Myocardial Infarction in Rats. Research Journal of Pharmacology and Pharmacodynamics.2025;17(3):181-7. doi: 10.52711/2321-5836.2025.00030 Available on: https://rjppd.org/AbstractView.aspx?PID=2025-17-3-5
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